Our Lab is part of the TEMPO Group
Located in the Department of Physiology and Biophysics in the School of Medicine of the University of California at Irvine, we work on biophysical problems related to the folding and stability of membrane proteins. We are part of the UCI Structural Biology and Molecular Biophysics graduate program. Our research is supported by the National Institute of General Medical Sciences and the National Institute of Neurological Disorders and Stroke.
All of the resources described below are available from a single "quick and easy" Web page. Our home page is by-passed.
Membrane Proteins of Known 3D Structure : A current list of membrane protein structures determined by x-ray and electron diffraction with links to the Protein Data Bank and other useful sites.
MPtopo is a curated database of membrane proteins with experimentally validated transmembrane (TM) segments. The database is maintained in SQL form using the MySQL server. It can be searched using MPtopoQuerier, a java applet developed for this purpose. Retrieved sequences can be examined automatically by MPEx, a java-based hydropathy-plot tool (below).
Membrane Protein Explorer (MPEx) is a java-based tool for exploring the topology and other features of membrane proteins by means of hydropathy plots, using thermodynamic principles developed in our laboratory. It incorporates and provides access to another tool: the Membrane Protein Topology (MPtopo) database. Opens in new window.
Web sites of interest to structural biophysicists including membrane biophysics resources, structure and sequence databases, general biological Web sites including visible human viewer, other useful sites such as the CIA World Factbook, and Californiana!
From Frontiers in Membrane and Membrane Protein Biophysics: Experiment and Theory Symposium, August 2010