>3D_other;124
protein_name:fatty acid amide hydrolase* (Rattus norvegicus)
file_name:FAAH.txt
entry_date:13may03
refman_number:20709
endnote_number:
author:Bracey,M.H., Hanson,M.A., Masuda,K.R., Stevens,R.C., Cravatt,B.F. (2002) [Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling] {Science, 298, 1793-1796}
remarks:Monotopic membrane protein. Although this protein has a single transmembrane segment (tmseg A), it is classified as monotopic because the active site is external to the membrane. The binding of the protein to membranes is unaffected by removal of tmseg A. 'tmseg' B below refers to a helix-turn-helix motif that causes tight membrane association. Sequence is from Swiss-Prot. TMhelices=1.
pir_number:
Swiss_Prot_entry:FAAH_RAT
Swiss_Prot_number:P97612
Swiss_Prot_gene:FAAH
Swiss_Prot_name:Fatty-acid amide hydrolase
PDB_title:Fatty Acid Amide Hydrolase
PDB_Identifier:1MT5
N_terminal:out
number_tmsegs:2
tm_segments:A.7,29;B.410,438
sequence:MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS*