Publications

• Dasgupta, G., and Reisler, E. Antibody against the amino terminus of actin inhibits Actomyosin interactions in the presence of ATP. J. Mol. Biol., 1989:833-836.
• Dasgupta, G., White, J., Phillips, M., Bullinsky, J.C., and Reisler, E. Immunochemical probing of the N-terminus segment on Actin: the Polymerization reaction. Biochemistry, 1990:3319-24.
• Dasgupta, G., White, J., Cheung, P., and Reisler, E. Interactions between G- Actin and Myosin Subfragment-1: Immunochemical probing of the amino terminal segment on Actin. Biochemistry, 1990:8503-08.
• Adams, S., Dasgupta, G., Chalovich, J.M., and Reisler, E. Immonochemical evidence for the binding of Caldesmon to the amino terminus of Actin. J. Biol. Chem., 1990:19652-19657.
• Dasgupta, G., and Reisler, E. Nucleotide induced changes in the interaction of Myosin Subfragment-1with Actin: Detection by antibodies against the N-terminal segment of Actin. Biochemistry, 1991:9961-9966.
• Dasgupta, G., and Reisler, E. Actomyosin interactions in the presence of ATP and the N-terminal segment of Actin. Biochemistry 1992:1836-1841.
• Cartoux, L., Chen, T., Dasgupta, G., Chase, B.P., Kushmerick, J.M., and Reisler, E. Antibody and peptide probes of interactions between the SH1-SH2 region of Myosin Subfragment 1 and s N-terminus. Biochemistry, 1992:10929-10935.
• Brenner B, Kraft T, Dasgupta G., Reisler E. Cross-bridge binding to actin and force generation in skinned fibers of the rabbit psoas muscle in the presence of antibody fragments against the N-terminus of actin. Biophys J., 1996:48-56.
• Sepehrnia, B., Paz, I.B., Dasgupta, G., and Momand, J. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. J. Biol. Chem., 1996:15084-15090.
• Dasgupta, G., and Momand, J. Geldanamycin prevents nuclear translocation of mutant p53. Exp. Cell. Res., 1997:29-37.
• Li, J.R., Chou, K.C., McDougall, J.A., Dasgupta, G., Wu, H.H., Ren, L. R., Lee, A., Han, J., and Momand, J. P53 tumor suppressor protein in normal human fibroblasts does not respond to 837 MHz CW microwaves exposure. Radiation Research, 1999:710-716.
• Momand, J., Wu, H.H., and Dasgupta, G. MDM2-Master Regulator of the p53 Tumor Suppressor Protein. Gene, 2000:15-29.
• Nesburn AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL, BenMohamed L. Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. J Virol., 2007:7647-61.
• Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S,Wechsler SL, Nesburn AB, BenMohamed L. HLA- A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. J Immunol., 2008:426-37.
• Renaudet O, BenMohamed L, Dasgupta G, Bettahi I, Dumy P. Towards a self- adjuvanting multivalent B and T cell epitope containing synthetic glycolipopeptide cancer vaccine. ChemMedChem., 2008:737-41.
• Bettahi I, Dasgupta G, Renaudet O, Chentoufi AA, Zhang X, Carpenter D, Yoon S, Dumy P, BenMohamed L. Antitumor activity of a self-adjuvanting glyco- lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes. Cancer Immunol. Immunother., 2009:187-200.
• Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L. A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunol., 2009:129-43.
• Dasgupta G, Chentoufi AA, Wechsler SL, BenMohamed L. New Concepts in Herpes Simplex Virus Vaccine Development: Notes and Challenges from the Battlefield. Expert Review of Vaccines, 2009:1023-35.
• Dasgupta G, Nesburn AB, Wechsler SL, BenMohamed L. Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiol, 2010:1-4.
• Chentoufi AA, Dasgupta G, Nesburn AB, Bettahi I, Binder NR, Choudhury ZS, Chamberlain WD, Wechsler SL, BenMohamed L. Nasolacrimal duct closure modulates ocular mucosal and systemic CD4 (+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol., 2010:342-53.
• Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB,Wechsler SL, BenMohamed L. A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope- based vaccines against ocular herpes. J Immunol., 2010:2561-71.
• Renaudet O, Dasgupta G, Bettahi I, Shi A, Nesburn AB, Dumy P, BenMohamed L. Linear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunity. PLoS One., 2010:e11216.
• Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, Benmohamed L. Engagement of TLR2 Reverses the Suppressor Function of Conjunctiva CD4+CD25+ Regulatory T Cells and Promotes Herpes Simplex Virus Epitope-Specific CD4+CD25-Effector T Cell Responses. Invest Ophthalmol Vis Sci., 2011:3321-33.
• Dasgupta G, Benmohamed L. Of mice and not humans: how reliable are animal models for evaluation of herpes CD8(+)-T cell-epitopes-based immunotherapeutic vaccine candidates? Vaccine, 2011:5824-36.
• Chentoufi AA, Kritzer E, Tran MV, Dasgupta G, Lim CH, Yu DC, Afifi RE, Jiang X, Carpenter D, Osorio N, Hsiang C, Nesburn AB, Wechsler SL, BenMohamed L. The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J Virol., 2011:9127-38.
• Dasgupta G, Chentoufi AA, Kalantari M, Falatoonzadeh P, Chun S, Lim CH, Felgner PL, Davies DH, Benmohamed L. Immunodominant "Asymptomatic" Herpes Simplex Virus 1 and 2 Protein Antigens Identified by Probing Whole-ORFome Microarrays with Serum Antibodies from Seropositive Asymptomatic versus Symptomatic Individuals. J Virol., 2012:4358-69.
• Kalantari-Dehaghi M, Chun S, Chentoufi AA, Pablo J, Liang L, Dasgupta G, Molina DM, Jasinskas A, Nakajima-Sasaki R, Felgner J, Hermanson G, Benmohamed L, Felgner PL, Davies DH. Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling. J Virol., 2012:4328-39.
• Chentoufi AA, Dervillez X, Dasgupta G, Nguyen C, Kabbara KW, Jiang X, Nesburn AB, Wechsler SL, Benmohamed L. The Herpes Simplex Virus Type 1 Latency-Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells. Viral Immunol., 2012 Apr 18.

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A Brief Curriculum Vitae

• 2009- present: University of California at Irvine, USA (Associate Specialist II)
• 2006-2009: University of California at Irvine, USA (SRA III)
• 2003-2006: University of California at Irvine, USA (SRA III)
• 2001-20093: Alpha Therapeutic Corporation, California, USA (Project Scientist)
• 1999-2001: Children Hospital of Orange County, California, USA (Research Associate)
• 1994-1999: City of Hope Cancer Research Center. California, USA (Research Fellow)
• 1991-1994: University of California, Los Angeles, USA (Post doctoral Fellow)
• 1987-1991: University of California, Los Angeles, USA (Laboratory Assistant)
• 1981-1987: University of Calcutta, India (Ph.D. student)

Research Interests

My project involves the expression and purification of "Voltage Sensing Domain" (VSD), a specialized transmembrane segment of voltage-dependent K⁺ channel "KvaP" from Aeropyrum pernix. In addition, making of semi-synthetic VSD and mutated VSD also in the line of progress. In a collaborative study, all these VSDs will be used for neutron diffraction and x-ray diffraction study.

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