Welcome to
The Stephen White Laboratory at UC Irvine
Our Lab is part of the TEMPO Group
Located in the Department of Physiology and Biophysics in the School of Medicine of the University of California at Irvine, we work on biophysical problems related to the folding and stability of membrane proteins. We are part of the UCI Structural Biology and Molecular Biophysics graduate program. Our research is supported by the National Institute of General Medical Sciences.
Research Interests and Programs
- Membrane Protein Folding and Stability
- Energetics of Protein-Bilayer Interactions
- Experimentally Determined Hydrophobicity Scales
- Translocon-assisted Folding of Membrane Proteins
- Structure of Fluid Lipid Bilayers
- MD Simulations of Lipid Bilayers
- MD Simulations of Membrane Proteins
Members of the Laboratory
- Stephen H. White, Distinguished Professor, Emeritus
- Craig Snider, Software Engineer
- Gargi Dasgupta, Lab Manager
- Eric Lindner, Assoc. Specialist
- Guillaume Roussel, Postdoc Researcher
- Alfredo Freites, Asst. Project Scientist (Chemistry)
Laboratory Alumni
- Magnus Andersson, Postdoctoral Researcher
- Ryan Benz
- Nicoleta Bondar, Free University of Berlin
- Sara Capponi, University of California, San Francisco
- Francisco Castro-Román, Cinvestav-IPN, Mexico City
- Mónica Fernández-Vidal
- Kalina Hristova, Johns Hopkins University
- Simon Jaud
- Sajith Jayasinghe, Calif. State University at San Marcos
- Alexey S. Ladokhin, University of Kansas Medical Center
- Ella Mihailescu, University of Maryland | NIST
- Hirotaka Sasaki, Kanagawa Academy of Science and Technology, Japan
- Eric Schow, Postdoc Researcher (Chemistry)
- Martin Ulmschneider, King's College, London
- Michael C. Wiener, University of Virginia
- William C. Wimley, Tulane University
- Mike Myers, lab manager/copy editor
News
Text searching of the mpstruc protein table is now available
A new user interface for the mpstruc protein table is now available
All of the resources described below are available from a single "quick and easy" Web page. Our home page is by-passed.
Membrane and Protein Biophysics Resources
Membrane Proteins of Known 3D Structure : A current list of membrane protein structures determined by x-ray and electron diffraction with links to the Protein Data Bank and other useful sites.
MPtopo is a curated database of membrane proteins with experimentally validated transmembrane (TM) segments. The database is maintained in SQL form using the MySQL server. It can be searched using MPtopoQuerier, a java applet developed for this purpose. Retrieved sequences can be examined automatically by MPEx, a java-based hydropathy-plot tool (below).
Version 3.3.1 Now Available!
Membrane Protein Explorer (MPEx) is a java-based tool for exploring the topology and other features of membrane proteins by means of hydropathy plots, using thermodynamic principles developed in our laboratory. It incorporates and provides access to another tool: the Membrane Protein Topology (MPtopo) database. Opens in new window.
Reprints of Laboratory Publications
Structural Biophysics Web Resources
Web sites of interest to structural biophysicists including membrane biophysics resources, structure and sequence databases, general biological Web sites including visible human viewer, other useful sites such as the CIA World Factbook, and Californiana!
Symposium Photo Album
From Frontiers in Membrane and Membrane Protein Biophysics: Experiment and Theory Symposium, August 2010
Author:
©1998-2024 Stephen H. White. All rights reserved
Local Time: Wednesday, 06-Nov-2024 16:05:18 PST
Header Background Image: Bacteriorhodopsin (1C3W) at 1.55 Å resolution
Site modified: 30 October 2024. Page design modified: 8 June 2024
